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KMID : 0380919960250020232
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Journal of the Korean Society of Food Nutrition
1996 Volume.25 No. 2 p.232 ~ p.239
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Antimutagenic Effects of Persimmon Leaf Tea Extracts in Sister Chromatid Exchange(SCE) Assay System
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Song Hyun-Soon
Lee Hyun-Kul
Jang Hae-Dong
Kim Jong-Ik
Park Ock-Jin
Lee Mee-Sook
Kang Myung-Hee
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Abstract
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The antimutagenic effects of persimmon leaf tea extracts(PLTE) on mutagen-induced sister chromatid exchanges(SCEs) were studied. These PLTE did not affect spontaneous SCEs in cultured Chinese hamster cells. The frequency of SCEs induced by mitomycin C(MMC) was not affected by the simultaneous treatment with PLTE without S9 mixture in the S phase of the cell cycle. However, when cells were posttreated with PLTE in the presence of metabolic enzymes of rat liver(S9 mix), the antimutagenic effects on the induction of SCEs by mutagen were observed. MMC-induced SCEs were suppressed by the posttreatment with PLTE at low concentrations(≤40㎍/ml) with S9 mix. In contrast, at a high concentration(＞40㎍/ml) of PLTE with S9 mix, MMC-induced SCEs were not affected. The antimutagenic effects of PLTE were shown to occur in the G₁ phase of the cell cycle. The results suggested that PLTE could promote DNA-excision repair activity and resulted in an antimutagenic effect.
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KEYWORD
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persimmon leaf tea extract, sister chromatid exchanges(SCEs), antimutagenic effect, Chinese hamster ovary cell
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